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  2. Chung Shan Medical University
  3. Project/研究計畫(老師)
  4. 探討脊髓電刺激對缺血性中風之作用
 
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探討脊髓電刺激對缺血性中風之作用

  • Details
Project title
114學年度國家科學及技術委員會補助研究計畫
Acronym
專題研究計畫
Internal ID
NSTC114-2320-B040-025-MY3
Principal Investigator
Su, Hsing-Hui  
Status
research project
Start Date
November 1, 2025
End Date
October 31, 2026
Organizations
Department of Medical Laboratory and Biotechnology  
Partner Organizations
National Science and Technology Council  
Project Web Site
https://www.grb.gov.tw/search/planDetail?id=18623004
Keywords
脊髓電刺激
缺血性中風
腦血流
神經保護
感覺運動功能
Description
內生性調控血流的機制不足以有效減少缺血性中風所造成的損傷。脊髓刺激(Spinal Cord Stimulation, SCS)可增強組織灌流,並緩解與周邊血管疾病相關的缺血性損傷。先前研究發現,SCS可在缺血性中風後增加腦血流,並改善臨床病患的運動功能。然而,儘管已知SCS對缺血性中風患者而言是安全的,其治療效益尚未被充分評估,且對其詳細機制的理解仍然不足。
本研究將探討SCS對缺血性中風的神經保護作用及其作用機制。我們將透過基礎與臨床實驗驗證SCS是否能藉由影響中樞或周邊自主神經系統,調節具血管擴張特性的神經傳導物質釋放,進而增加腦血流、改善腦部損傷、血管新生、神經再生及感覺運動功能表現。完成本研究計畫後,我們將能夠開發一項具有高度潛力的新療法,以改善中風預後並擴展SCS的醫療適應症。
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