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  4. DMBA誘發口腔癌之發育過程中倉鼠淋巴球染色體-系列變化之研究
 
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DMBA誘發口腔癌之發育過程中倉鼠淋巴球染色體-系列變化之研究

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Project title
82學年度國家科學及技術委員會補助研究計畫
Acronym
專題研究計畫
Internal ID
NSC82-0412-B040-010
Principal Investigator
Chou, Ming-Yung  
Status
research project
Start Date
August 1, 1992
End Date
July 31, 1993
Organizations
School of Dentistry  
Partner Organizations
National Science and Technology Council  
Project Web Site
https://www.grb.gov.tw/search/planDetail?id=24784
Keywords
化學致癌物
染色體分析
癌化
Description
本研究以對DMBA(7,12-dimethylbenz-anthracene)誘發癌 發育過程中分析染色體之變化.用不同濃度之DMBA( 0.1,0.25,0.5%)塗抹於SYRIANHamster倉鼠之頰囊(cheek pouch),塗抹時間由第1週至第14週,血液抽取由第8週 開始至18週,每隔兩週由頸靜脈抽取血液,經培養製備染色體以分析其變化,包括G染色帶核型圖(G- Bandingkaryotype)分析.斷裂及隙裂分析,期望能發現 某一特定部位是否最易損傷,對於DMBA致癌作用有 更近一步的瞭解.
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