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  4. 探討DNA損傷相關蛋白GADD45A 在新穎化合物GO-Y030誘發口腔癌細胞凋亡之角色
 
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探討DNA損傷相關蛋白GADD45A 在新穎化合物GO-Y030誘發口腔癌細胞凋亡之角色

  • Details
Project title
114學年度國家科學及技術委員會補助研究計畫
Acronym
專題研究計畫
Internal ID
NSTC114-2314-B040-011
Principal Investigator
Chang, Yu-Chao  
Status
research project
Start Date
August 1, 2025
End Date
July 31, 2026
Organizations
School of Dentistry  
Partner Organizations
National Science and Technology Council  
Project Web Site
https://www.grb.gov.tw/search/planDetail?id=17970975
Keywords
口腔癌
GO-Y030
薑黃素衍生物
細胞凋亡
訊息傳遞路徑
動物模式
Description
口腔癌病人五年之存活率約60%。但若能更有效抑制癌細胞的生長,將可大幅減低癌症的死亡率。因此,了解 GO-Y030 在誘導不同口腔癌細胞株細胞凋亡之機制,可以利用一些抑制劑來輔助治療並降低抗癌藥物的副作用,可提高口腔癌患者的存活率。另外,執行本計畫也可以在學術發展方面對台灣的口腔癌研究盡一份心力。
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