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  2. Chung Shan Medical University
  3. Project/研究計畫(老師)
  4. 探討醛酮還原酶1C之角色及分子機制在梅笠草素參與鼻咽癌細胞鐵凋亡進程及其輔助順鉑治療應用
 
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探討醛酮還原酶1C之角色及分子機制在梅笠草素參與鼻咽癌細胞鐵凋亡進程及其輔助順鉑治療應用

  • Details
Project title
114學年度國家科學及技術委員會補助研究計畫
Acronym
專題研究計畫
Internal ID
NSTC114-2320-B040-020
Principal Investigator
Chuang, Chun-Yi  
Status
research project
Start Date
August 1, 2025
End Date
July 31, 2026
Organizations
School of Medicine  
Partner Organizations
National Science and Technology Council  
Project Web Site
https://www.grb.gov.tw/search/planDetail?id=17967796
Keywords
鼻咽癌
梅笠草素
醛酮還原酶1C1
細胞凋亡
活性氧分子
鐵凋亡
脂質過氧化
順鉑
Description
本計畫學術價值是提供證實天然藥物Chimaphilin誘導鼻咽癌鐵凋亡作用機制是透過氧化壓力調控AKR1C1表現,並且有效輔助cisplatin治療鼻咽癌功效。未來期望發展成為特定化療藥物輔助治療鼻咽癌的中醫藥,以提升鼻咽癌患者的生活品質。
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