不同成分根尖充填劑植入老鼠之生物效應比較

An ideal root end filling material should be biocompatible with dental tissues and
create a local environment that is conductive to pulpal healing or osseous healing.
The root end filling materials has been studied in our laboratory. The previous
studies are found that the root end filling materials treated U2OS cells are dose
dependent biocompatibility. At high concentrations of the root end filling material
showed that U2OS cells apoptotic change. The other findings showed that mineral
trioxide aggregate is cytocompatible with U2OS cell line. The DNA fragment assay
of the U2OS cells, after treated with MTA, showed that no DNA fragmentation. The
MAPK kinase regulation of the MTA treated cell is by ERK kinase pathway. These
results showed clinically used root end filling materials are biocompatible in vitro.
But there is scant article discussed root end filling material treated on animal in vivo.
The purpose of the present study is to compare the effects of different root end
materials implanted in Balb/c mice. The cytokine expression, pathological change on
tissue and biochemical assay of the blood are planning to explore. It is hoped that
present study can offer more information on the selecting root end filling materials.