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Chung Shan Medical University
Project/研究計畫(老師)
檳榔素活化LINC01446/miR-489 axis調控糖解作用對口腔黏膜下纖維化症促進之研究及臨床應用
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檳榔素活化LINC01446/miR-489 axis調控糖解作用對口腔黏膜下纖維化症促進之研究及臨床應用
Details
Primary Data
Project title
114學年度國家科學及技術委員會補助研究計畫
Acronym
專題研究計畫
Internal ID
NSTC112-2314-B040-022-MY3
Principal Investigator
Lee, Yu-Hsien
Status
research project
Start Date
August 1, 2025
End Date
July 31, 2026
Organizations
School of Dentistry
Partner Organizations
National Science and Technology Council
Project Web Site
https://www.grb.gov.tw/search/planDetail?id=18141022
Description
Keywords
檳榔素
口腔黏膜下纖維化症
LINC01446
miR-489
Description
嚼食檳榔是造成口腔黏膜下纖維化症主因且目前口腔癌黏膜下纖維化症尚缺有效治癒療法。本研究將釐清檳榔鹼活化長鏈非編碼核醣核酸LINC01446於調控肌纖維母細胞糖解作用導致口腔黏膜下纖維化症的分子機制,提供病患未來治療基礎的實證,將對於個人化精準醫療有所貢獻。
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