均衡營養代餐包配合熱量限制對減重效益之研究

近十多年來肥胖人口發生率有逐漸增加之趨勢，也成為全球重要的公共衛生問題。隨著肥胖發生率越來越高，肥胖相關代謝症候群的發生也逐年攀升。因此，預防及控制肥胖可以降低其相關代謝性疾病之發生。本研究以均衡營養飲品作為代餐探討對於減重之效益，招募BMI>27之肥胖個案，納入符合條件共50位(男性23位、女性27位)，限制男性每日總熱量於1500大卡，女性每日總熱量在1200大卡，每日提供兩餐各一份均衡營養代餐包，介入期共8週，比較試驗前後減重之成效。分別測量體位、血液生化值及心血管疾病和發炎的相關指標；試驗期間也紀錄飲食攝取(24小時回憶法及三天飲食紀錄法)。結果顯示，代餐介入八週後，顯著減輕4.1公斤體重、2.38%體脂肪，及5.06公分腰圍。另外，血清總膽固醇、三酸甘油酯及低密度脂蛋白膽固醇皆顯著下降，高密度脂蛋白膽固醇顯著上升，胰島素、HOMA-IR、瘦體素、脂質過氧化程度及心血管疾病相關指標亦有顯著性改善。因此可知，以均衡營養代餐包介入，確實具有減重之成效，且有減少心血管疾病風險之益處。

The prevalence and health problem of obesity have increased significantly in recent decades and become an important public health issue. Increasing obesity prevalence comes together with metabolicsyndrome. The prevention and control of obesity can reduce the related metabolic diseases. In this study, meal replacement intervention was used to evaluate the efficacy of weight loss. Obese subjects (BMI>27) were recruited in this study (n=50, male 23, female 27). Daily calorie intake was restricted to 1500 kcal/day for man and 1200 kcal/day for woman. All subjects received meal replacements twice a day for 8 weeks. After eight weeks of intervention, the body weight, body fat and waist circumference were significantly reduced by 4.1kg, 2.38% and 5.06cm, respectively. Total serum cholesterol, triglycerides and low-density lipoprotein cholesterol were significantly decreased (p<0.05), high-density lipoprotein cholesterol was significantly increased (p<0.05). Insulin, homeostatic model assessment-insulin resistance (HOMA-IR), leptin, thiobarbituric acid reactive substances (TBARS) and the coronary risk index were all significantly improved (p<0.05). In conclusion, the intervention of meal replacement along with caloric restriction was effective in weight loss and beneficial to the prevention of cardiovascular diseases.