The relevance of serum anti-müllerian hormone levels, chronological age and embryo quality to the outcome of assisted reproduction technology cycles

Background Anti-Müllerian hormone (AMH) has been reported to be intimately correlated to pregnancy outcome in IVF cycles, although some conflicting results also exist in the medical literature. This study intended to assess the capability of combining of AMH and embryo quality as predictors of pregnancy outcome. Methods A prospective cohort of 404 IVF/ICSI cycles was investigated. In order to evaluate the predictive value for pregnancy in IVF cycles based on chronologic age, basal FSH level, basal AMH level, and antral follicle count (AFC), together with certain embryorelated parameters, ROC curve analysis and logistic regression model were utilized. Results The basal serum AMH level (odds ratio: 1.222~1.978) and chronologic age (odds ratio: 0.637~0.929) were the major predictive factors of pregnancy for women older than 35 years of age. Regarding the young age group, the number of transferred embryos (odds ratio: 1.199~1.745) and the rate of good embryos (odds ratio: 1.149~7.510) were the main predictors of successful treatment by IVF. Conclusion The basal serum AMH level is a useful tool to provide a realistic probability of pregnancy for counseling purposes, especially for women older than 35 years of age.