Abstract 717: Erianin induces autophagy-dependent apoptosis in oral cancer cells

<jats:title>Abstract</jats:title>
<jats:p>Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide. It has a very poor prognosis with 5-year over survival rate of only 50%. Thus, it is important to identify effective therapeutic interventions against oral cancer. The present study was designed to evaluate the effect of erianin, a natural bibenzyl compound found in a traditional Chinese orchid Dendrobium chrysotoxum, on human oral cancer cell proliferation. Results of the study revealed that treatment with erianin significantly reduced the viability of different OSCC cell lines. Erianin exerted its cytotoxic effect by inducing cell cycle arrest at G2/M phase and caspase-dependent apoptotic pathways. Both intrinsic and extrinsic pathways were found to be involved in erianin-mediated cell death. In addition, treatment with erianin also increased autophagy in OSCC cells. With further analysis, it was found that erianin induced both apoptosis and autophagy by regulating MAPK signaling pathways. Taken together, our study indicates that erianin plays an important role in reducing oral cancer cell viability, and thus, can be considered as a potential anticancer agent.</jats:p>
<jats:p>Citation Format: Chiao-Wen Lin, Shun-Fa Yang. Erianin induces autophagy-dependent apoptosis in oral cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 717.</jats:p>