Fatigue Level Associated with Quality of Life for Prostate Cancer Patients: Results from the All of Us Research Program

<jats:p>Background/Objectives: Prostate cancer (PCa) patients frequently experience extended survivorship, highlighting the importance of quality of life (QoL) in cancer care. QoL has been shown to influence survival and PCa progression. For PCa patients, fatigue is a common issue due to cancer itself or its treatments. However, many QoL studies on PCa patients are limited by small sample sizes in clinic settings and often overlook the impact of fatigue and health-related behaviors. To fill this gap, this study aims to evaluate fatigue associated with QoL and related health measures among PCa patients. Methods: This study used the All of Us cohort with 6426 PCa patients. Factors associated with QoL and health outcomes were tested using logistic models. Results: Among PCa patients, 8.8% reported poor QoL, 20.9% reported poor physical health, and 9.0% reported poor mental health. Around 24.5% and 5.0% of PCa patients had a moderate and high fatigue level, respectively. A high fatigue level was significantly associated with poor QoL (OR = 2.33, p < 0.001), poor physical health (OR = 8.20, p < 0.001), and poor mental health (OR = 3.62, p < 0.001), adjusting for other factors. Social function ability also played a critical role in QoL and health outcomes. In addition, PCa therapy was associated with a higher risk of poor physical health (OR = 1.30, p = 0.030) but not associated with QoL and mental health. Conclusions: This study provides valuable insights about fatigue’s important role in QoL, physical health, and mental health for PCa patients. Effective fatigue management is suggested to enhance QoL and overall well-being for PCa patients.</jats:p>