攝取含三種益生菌脫脂奶對血脂質調節之影響

本研究以人體臨床試驗探討攝取含三益菌脫脂奶對血脂質調節的影響。將38位血脂較高但未服用降血脂藥物之成年人隨機分成二組，一組（n=19）攝食含添加Lactobacillus acidophilus、Lactobacillus casei及Bifidobacterium lactis三株益生菌的A配方脫脂奶粉之沖泡牛奶。另ㄧ組（n=19）則攝食無添加益生菌之B配方脫脂奶粉之沖泡牛奶。本研究試驗分成三個階段，第一階段為一週的飲食調整期（run-in period），第二階段為十週的攝食期（administration period），每位受試者每天攝取2包（每包30公克）脫脂奶粉之沖泡奶，第三階段為停止攝食後，為期2週的觀察期（follow-up period）。結果發現，受試者攝食含有三益菌A配方脫脂奶連續二週後，血漿中的總膽固醇（TC）和低密度脂蛋白膽固醇（LDL-C）含量即有顯著的下降（p<0.05）。但對於血漿中的三酸甘油酯（TG）和高密度脂蛋白膽固醇（HDL-C）則無顯著的影響。此外，在連續攝食含有三益菌A配方脫脂奶十週後，低密度脂蛋白之氧化遲滯時間（LDL lag time）則有顯著的增加。然而，食用不含益生菌之ㄧ般脫脂奶對血脂則無影響。

This study was to evaluate the effect of consumption of three probiotics- containing skim milk formula on plasma lipid regulation for adults with board line hyperlipidemia. Thirty-eight adults without taking lipid-lowering medicine were randomly divided into two groups,（1）formula A (n=19), milk with probiotics（Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium lactis）（2）formula B（n=19), milk without probiotics. The total experimental duration of this study was 13 weeks. One week before experiment was run-in period. Ten weeks of continuous ingestion of formula A or formula B were administration period. Extra two weeks after administration were follow-up period. Results showed that the levels of total plasma cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly decreased after the administration of formula A. But the levels of plasma triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) showed no change. In addition, ten weeks of continuous administration with formula A greatly increased the lag time of low-density lipoprotein oxidation. The use of normal skim milk without probiotics (formula B) did not affect the plasma lipids.