Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives

Background: Family history of gout and sex are independently associated with gout. However, there is a paucity of research regarding the joint role of both factors in gout pathogenesis. Therefore, we assessed the independent and combined association of family history of gout and sex with gout. Methods: Our analysis included 132,311 Taiwan Biobank (TWB)-enrolled individuals comprising 21,159 gout cases and 111,152 controls. We subcategorized the family history of gout as (1) both siblings and parents had gout), (2) only parents had gout, and (3) only siblings had gout. Results: Generally, sex (men compared to women) and family history of gout were independently associated with a higher risk of gout. The odds ratio (OR); 95% confidence interval (CI) was 9.175; 8.801–9.566 for sex, and 2.306; 2.206–2.410 for family history. For the subcategories ‘both siblings and had gout,’ ‘only parents had gout,’ and ‘only siblings had gout,’ the odds ratios (ORs); 95% confidence intervals (CIs) were 4.944; 4.414–5.538, 2.041; 1.927–2.161, and 2.162; 2.012–2.323, respectively. The interaction between sex and family history was significant (p value = 0.0001). After stratification by sex, family history of gout remained significantly associated with a higher risk of gout in both sexes, even though the odds ratios were higher in men. For the subcategories ‘both siblings and parents had gout,’ ‘only parent had gout,’ and ‘only siblings had gout,’ the corresponding ORs; 95% CIs were 6.279; 5.243–7.520, 2.211; 2.062–2.371, and 2.148; 1.955–2.361 in men and 4.199; 3.566–4.945, 1.827; 1.640–2.035, and 2.093; 1.876–2.336 in women. After integrating sex and family history (reference: women with no family history), the highest risk of gout was observed in men who had at least one parent and sibling with a history of gout (OR; 95% CI 55.774; 46.360–67.101). Conclusion: Sex and family history of gout were independently and interactively associated with gout. Sex-wise, men had a higher risk of gout than women. Family history was associated with a higher risk of gout in both sexes, but men had a higher risk. Notably, men having both siblings and parents with gout had the highest risk of gout.