新驅蟲藥Milbemycin Oxime對廣東住血線蟲幼蟲之療效

為了解神經性藥物milbemycin oxime對廣東住血線蟲之治療效果，選擇不同劑量之 milbemycin oxime 5.0mg/kgx1、 25.0mg/kgx1 及 5.0mg/kgx10 感染後第六天分別口服治療感染廣東住血線蟲第三期幼蟲之大白鼠，感染後第八週收集老鼠糞便檢查幼蟲數，第十五週解剖老鼠，計算肺臟重量與老鼠體重比、蟲體回收數；結果發現：對照組與治療組，其老鼠肺臟重量與老鼠體重比、蟲體回收數和幼蟲數都有顯著差異，而不同劑量之治療組之間，並沒有差異。
The main purpose of current study is to determine the efficacy of milbemycin oxime against Angiostrongylus cantonensis infection. Wistar rats with 20 infective larvae of the Angiostrongylus cantonensis were studied. Milbemyccin oxime was administraed orally at dose 5.0mg/kgx1,25.0mg/kgx1 and 5.0mg/kgx10 in separate on the 6th days after post-infection. Fifteen weeks after post-infection, the worm are recovered from these rats. There is no significant difference（p>0.05）among the three treatment groups in the effectiveness of milbemycin oxime against larval stage of Angiostrongylus cantonensis. But there is significant difference between the control group and the treatment group （p<0.05 ）.