Differential effects on fibroblast cells proliferation and migration by bismuth subgallate and borneol individual and combination

Bismuth subgallate (BSG) is a haemostatic agent and may reduce inflammation. Borneol (BO) usually exists in many essential oil which effects on antimicrobial and anti-oxidation. Besides, combination of BSG and BO stimulated wound closure rate and granulation tissue formation in a wound-thickness model and enhanced acute wound healing in the human forearm biopsy model. However, the mechanism of BSG combined with BO on wound healing is still unclear. From previous report, proposing RSu BO alone or combination may have beneficialeffect on fibroblasts proliferation and migration. Thus, this study focused on BSG and BO alone or combination on fibroblasts proliferation and m lgration influence, key role in wound repair. The results showed suitable specific ratio of BSG combined with BO have more efficiently on fibroblasts proliferation and migration than BSG/BO alone. In addition, BSG combined with BO induced migration and filopodia formation through PI3K pathway. Idl mRNA expression was increased by optimal ratio of BSG combined with BO. This investigation indicates that suitable combination of BSG and BO stimulated fibroblastic proliferation and migration which suggests these two traditional medicines also have efficiency on wound therapy by suitable combination.