芸香苷飲料調節血壓之研究

高血壓是心血管疾病主要危險因子之一，將血壓控制在正常範圍內，可減少罹患心血管疾病的危險性。體外及動物研究發現，芸香苷（rutin）能抑制血管收縮素轉化酶及醛固酮的濃度而調降血壓。本研究目的在探討給予高血壓前期及第一期個案補充由蕎麥萃取之芸香苷飲料對其血壓的影響。研究採隨機對照試驗，共有45名受試者全程參與，試驗組每日補充2罐芸香苷飲料（60 mg rutin），連續12週。結果發現，試驗組之收縮壓（β = -0.503，p ＜ 0.001）及舒張壓（β = -0.458，p ＜ 0.001）的調降效果皆顯著大於對照組。血管縮收素I及II在兩組中無顯著變化；試驗組對血管收縮素轉化酶（β = -1.277，p ＜ 0.001）及醛固酮（β = -2.943，p = 0.042）的調降效果皆顯著大於對照組。此外，血管收縮素轉化酶亦與收縮壓（R = 0.601，p = 0.002）及舒張壓（R = 0.423，p = 0.039）呈顯著正相關。因此，本研究發現，每日補充2罐芸香苷飲料能輔助調降血管收縮素轉化酶和醛固酮的濃度，且顯著調降收縮壓和舒張壓。

Hypertension is one of the major risk factors for cardiovascular disease. Controlling blood pressure within the normal range can help to reduce the risk. Previous studies have found that rutin can inhibit angiotensin converting enzyme activity and reduce aldosterone to lower blood pressure in vitro and in vivo. The purpose of this study was to investigate the regulatory effect of rutin drink on blood pressure. In a randomized controlled trial, the experiment group received 2 cans of test drinks (60 mg rutin) daily for 12 consecutive weeks. The results showed that systolic blood pressure (β = -0.503, p < 0.001) and diastolic blood pressure (β = -0.458, p < 0.001) were significantly lowered in the experiment group. There was no significant change in angiotensin I and angiotensin II concentration in both groups. The reduced level of angiotensin converting enzyme (β = -1.277, p < 0.001) and aldosterone (β = -2.943, p = 0.042) concentration were found in the experiment group. In addition, angiotensin converting enzyme also showed positive correlations with systolic blood pressure (R = 0.601, p = 0.002) and diastolic blood pressure (R = 0.423, p = 0.039). Therefore, we conclude that the daily supplement of 2 cans of rutin drinks can help to downregulate blood pressure by lowering the concentration of angiotensin converting enzyme and aldosterone.