非類固醇藥物對中樞神經系統之藥理作用及精神壓力型消化性潰瘍發生之機轉

非類固醇藥物於臨床使用上，各類藥物均有不同的作用機轉，雖然本類藥物具有極佳的抗炎解熱鎮痛的臨床效果，可是其誘發胃潰瘍之不良副作用，亦是件不可忽視的事實，為了要闡明本類藥物不同之藥效及不良副作用與中樞神經之相關性，以醋酸扭體法、Carrageenin 誘發浮腫法、浸水緊張法試驗來探討鎮痛作用、抗炎作用、自發運動量抑制作用、精神壓力型胃潰瘍之影響、與腦內單氨含量變化之測定．獲得如下結論：(1)各類藥物均有抑制動物自發運動的效果，其中以Mefenamic acid及Ibuprofen 之抑制率最強（P<0.001）(2)鎮痛的效果以Ibuprofen為最好（P<0.001）(3)抗炎作用以Mefenamic acid及Aspirin最佳（P<0.001）(4)精神壓力型之胃潰瘍以Ibuprofen給藥群達到平均長度722mm為此四類中較為嚴重者，其次為Aspirin (5)腦組織中Monoamine含量的變化情形，以胃潰瘍最嚴重的Ibuprofen，其中鼠腦中Serotonin 含量最多，而其代謝物5HIAA含量最少，顯示Serotonin含量的多寡與胃潰瘍程度成正比。

Cinically, each and every group of non-steroid drug has its specific mechanism and effect. Even though the non-steroid medicine works wonder clinically in antiphlogistic, antipyretic and pain-killing treatment, the fact that it induces gastrelcosis is the adverse side effect shall not be overlooked.　　In order to clarify in details various effects and adverse coolateral actions produced by the said medicine and its relation to center nervus, Acetic Acid writhing method, carrageenin Edma Method and confined water Dipping Method were employed to study the pain-killing and antiphlogistic effects, inhibition of autonomic movements, influence upon gastrelcosis resultant from mental stress and measurement of variation of Monoamine contained inside the brain. The conclusion is as follows:　　1) All categories of medicine had inhibiting effects on animal autonomic movements. Among them, Mefenamic acid and Ibuprofen were seen with the strongest inhibiting rate (p<0.001);　　2) For analgesic purpose, Ibuprofen was the best of all (P<0.001);　　3) For antiphlogosis, Mefenamic acid and Aspirin were on top of all (P<0.001)　　4) For induction to gastrelcoma under mental stress, the group fed with Ibuprofen reflected an average length of 722mm, ranking the most serious of all these four groups, followed immediately by the Aspirin-administered ones; and　　5) For variation of Monoamine contained in celebral tissue, Ibuprofen was the most serious to gastrelcoma. The rats contained serotonin in their brains much greater than the others, but the least of metabolic product of all (5HIAA). This indicated the content of serotonin was in a direct ratio to the degree of gastrelcosis.