甲基汞透過內質網壓力調控細胞凋亡及誘發神經元細胞死亡:其中以活性氧物種抑制AKT蛋白活化扮演關鍵角色

甲基汞(Methylmercury, MeHg)是眾所周知的環境汙染物質，人類藉由食用海洋魚類動物間接暴露甲基汞，在流行病學調查研究中發現在污染區中人體內血液含有累積的汞(> 40

Epidemiological studies have positively linked mercury exposure and neurodegenerative diseases. Methylmercury (MeHg), an organic form of mercury, is highly ubiquitous environmental toxicant and a well-known human neurotoxic agent that easily crosses the blood-brain barrier and causes irreversible injury in the central nervous system (CNS). However, the molecular mechanisms underlying MeHg-induced neurotoxicity remain unknown. Here, the present study found that Neuro-2a cells underwent apoptosis in response to MeHg (1-5