（甲基）安非他命戒癮者的冷熱抑制干擾物能力

台灣目前藥物濫用趨勢以（甲基）安非他命為大宗。過去研究已知成癮者抑制控制能力（Inhibition control）缺損是導致難以停止用藥的原因，但現有研究鮮少針對冷、熱抑制控制能力進行比較。本研究以flanker task來檢驗（甲基）安非他命戒癮者的冷與熱抑制干擾物能力（cool and hot resistance to distractor interference）。本研究招募（甲基）安非他命戒癮組、健康控制組參與者各20人，進行冷、熱情境兩階段的flanker task，並予（甲基）安非他命戒癮者填寫藥物使用調查問卷，以及藥物依賴嚴重度量表（Severity of the Dependence Scale, SDS），評估其對（甲基）安非他命的心理依賴程度。結果顯示：（1）（甲基）安非他命戒癮者在冷、熱情境下所測得的抑制干擾物能力與健康控制組皆無顯著差異；（2）（甲基）安非他命戒癮者在熱情境下的抑制干擾物能力與冷情境下的抑制干擾物能力無顯著差異；（3）（甲基）安非他命依賴組和無依賴組在冷情境的一致性序列效應（Congruent Sequence Effect, CSE）反應時間差有顯著差異。本研究顯示（甲基）安非他命依賴者在冷情境的抑制干擾物能力應比無依賴者差。

The current trend of drug abuse in Taiwan is dominated by methamphetamine. Previous studies have that deficiency of inhibition control among addicts is the reason contributing to the difficulty in discontinuing drug use. However, very few studies have compared cold and hot inhibition control in methamphetamine abstainers. This study employed the flanker task to examine the cold and hot resistance to distractor interference of methamphetamine abstainers. Twenty methamphetamine abstainers and twenty healthy controls were recruited in this study. Participants completed cool and hot versions of flanker tasks, counterbalanced across participants. Methamphetamine abstainers completed a drug use questionnaire and the Severity of the Dependence Scale (SDS) to assess their psychological dependence on methamphetamine. There were no significant differences in resistance to distractor interference between methamphetamine abstainers and healthy controls in both cold and hot versions. For methamphetamine abstainers, there were no significant resistance to distractor interference between cold and hot versions. There were significant differences in the congruent sequence effect (CSE) in the cold version between dependent and nondependent methamphetamine abstainers. This study suggests that high dependent methamphetamine abstainers may have worse cold resistance to distractor interference compared to non-dependent abstainers.