香檸檬萃取物對輕中度血脂異常成人之影響

香檸檬(Citrus bergamia)，源自義大利，富含類黃酮化合物，包括新橙皮苷(NeoHesperidin)、柚皮苷(Naringin)和新聖草次苷(Neoeriocitrin)，這些成分在調節血脂方面展現了積極的潛力。由於現代社會對血脂異常的處理主要依賴藥物，這些藥物雖然有效，但其副作用已受到關注。本研究目的為探討香檸檬萃取物對於輕中度血脂異常成人的影響，採隨機雙盲平行試驗，受試者為40-70歲中老年者，低密度脂蛋白膽固醇(LDL-C)介於100-159 mg/dl之間。受試者每天早餐飯後服用2顆香檸檬萃取物膠囊或安慰劑持續四個月，定期檢測體位、血脂及血糖數值、發炎反應指標以及肝腎功能，共檢測四次(T0、T2、T3、T4)，完成試驗分析者為112位。結果發現服用香檸檬萃取物膠囊四個月後，總膽固醇、低密度脂蛋白膽固醇、ApoB數值下降達顯著差異。另外，香檸檬組(BE)的HbA1c、Insulin與HOMA-IR與T0達顯著差異，安慰劑組則無變化。我們進一步比較香檸檬萃取物對低密度脂蛋白膽固醇起始值超過130mg/dL受試者的影響，結果顯示在低密度脂蛋白膽固醇相對較高的中度血脂異常族群中，血脂指標的改善幅度相對更為明顯，總膽固醇與低密度脂蛋白膽固醇的下降趨勢較整體平均變化幅度更大，反映香檸檬萃取物在血脂異常程度高者中，可能更具有調節效益。試驗結果表示香檸檬萃取物可輔助調節血脂及血糖，且無副作用。

Citrus bergamia (bergamot), native to Italy, is rich in flavonoids such as neohesperidin, naringin, and neoeriocitrin, which have shown promising effects on lipid regulation. Given the growing concerns about the side effects of conventional lipid-lowering drugs, this study aimed to evaluate the efficacy of bergamot extract in adults with mild to moderate dyslipidemia.In a randomized, double-blind, parallel-group trial, participants aged 40–70 years with baseline LDL-C levels between 100 and 159 mg/dL received two capsules of bergamot extract or placebo daily for four months. Body composition, lipid and glucose markers, inflammatory indicators, and liver and kidney function were assessed at four time points (T0, T2, T3, T4). A total of 112 participants completed the study.After four months, the bergamot group showed significant reductions in total cholesterol, LDL-C, and ApoB. Improvements were also observed in HbA1c, insulin, and HOMA-IR, with no significant changes in the placebo group. Further analysis revealed that participants with baseline LDL-C >130 mg/dL experienced more pronounced lipid improvements compared to the overall population, suggesting greater benefit in individuals with higher initial risk.These findings suggest that bergamot extract may serve as a safe and effective adjunct for improving blood lipid and glucose profiles, particularly in those with elevated LDL-C.These findings suggest that bergamot extract may assist in regulating blood lipids and glucose levels without causing adverse effects.