大腸直腸癌患者的維生素 B-6變化與同半胱胺酸、氧化壓力及抗氧化能力變化之關係

高維生素 B-6可能會降低同半胱胺酸濃度及氧化壓力，增加抗氧化能力進而影響大腸直腸癌的發生，不過這些關係尚未清楚。本研究目的是利用二年的追蹤探討大腸直腸癌患者的維生素 B-6濃度變化與同半胱胺酸、氧化壓力及抗氧化能力變化之關係。於臺中榮民總醫院大腸直腸外科招募 70 位大腸直腸癌患者於手術及/或化療結束後進行二年追蹤。在追蹤前及二年追蹤後抽取空腹血液分析維生素 B-6 (血漿磷酸比哆醛濃度)、氧化壓力指標 (丙二醛濃度)、總抗氧化能力、超氧歧化酶活性、穀胱甘肽相關酵素活性。大腸直腸癌患者追蹤後較追蹤前有顯著較高的氧化壓力指標、榖胱甘肽硫轉移酶活性及總抗氧化能力；但有顯著較低的同半胱胺酸濃度。血漿磷酸

High vitamin B-6 concentrations might decrease homocysteine levels and oxidative stress and increase antioxidant capacities, thereby possibly affecting the risk of colorectal cancer. The purpose of this 2 years of follow-up study was to examine the effects of vitamin B-6 change on the changes of plasma homocysteine, indicators of oxidative stress and antioxidant capacities in patients with colorectal cancer. Seventy patients with colorectal cancer were recruited and followed after the surgery or chemotherapy from the division of colorectal surgery of Taichung Veterans General Hospital, Taichung, Taiwan. Fasting blood samples were drawn at baseline and 2 years later to measure vitamin B-6 status (plasma pyridoxal 5’-phosphate, PLP), homocysteine, cysteine, oxidative stress indicator, glutathione and glutathione-dependent enzyme activities. Patients with colorectal cancer had significantly higher levels of malondialdehyde (MDA, oxidative stress indicator), trolox equivalent antioxidant capacity (TEAC) and glutathione S-transferase activity but had significantly lower levels of homocysteine after the follow-up. There were no significant differences in cysteine, glutathione, activities of glutathione peroxidase and superoxide dismutase before and after the follow-up. After adjusting for confounders, the changes of plasma PLP level had no associations with the changes of homocysteine, cysteine, MDA, TEAC, glutathione and activities of glutathione-dependent enzyme activities and superoxide dismutase. The changes of vitamin B-6 had no effect on plasma homocysteine, indicators of oxidative stress and antioxidant capacities in patients with colorectal cancer after 2 years of follow-up.