Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression

Background: CDK10 is involved in cell proliferation; however, the function of CDK10 in cell development remains unclear. Results: The knockdown of cdk10 results in the apoptosis of neural progenitor cells (NPCs) through enhanced raf1a expression. Conclusion: Zebrafish cdk10 exhibits an important function in neurogenesis by the modulation of the raf1a level during development. Significance: These findings emphasize the significance of cdk10 in NPC survival.