維生素C對健康成年人血漿脂質變化之研究

本篇研究，主要是要探討維生素C與血漿脂質的相關性。本研究是以199位男性為研究對象，所有參與者均為健康，無吸煙、無酗酒、及無服用藥物習慣者【包括維他命與礦物質補充劑】，年齡介於20-40歲，參與者隨機被分為八組【A組為控制組；B至H組為實驗組，分別添加維生素C劑量是15，30，40，50，60，70，和80毫克共七組】，進行四週每日維生素C不同劑量添加，然後再比較研究前和研究後參與者的營養素攝取及禁食血液中脂類及維生素C濃度，並探討其不同劑量的維生素C添加和血漿脂質濃度的相關性。研究前【一週】及研究期間【四週】進行五週飲食記錄。 結果顯示，平日有攝取較高維生素C量或添加50毫克及以上者，血漿三酸甘油酯濃度有明顯降低【E至H組減少了7.35%、7.11%、8.16%、及7.66%】。平日有攝取較高維生素C量或添加50毫克及以上者，血漿總膽固醇濃度也有達到顯著地降低【E至H組減少了5.35%、6.18%、6.59%、及5.61%】。平日有攝取較高維生素C量或添加50毫克及以上者，血漿低密度脂蛋白濃度有顯著地降低【E至H組減少了6.90%、7.50%、5.79%、及5.17%】。血漿葡萄糖與高密度脂蛋白濃度，並不會受到維生素C攝取和添加多寡所左右。心血管疾病危險指數，因E至H組的血漿總膽固醇濃度有明顯降低，所以心血管疾病危險指數也隨之降低【E至H組減少了4.16%、5%、4.1%、及5.5%】。維生素C添加後血漿三酸甘油酯的皮爾森相關係數﹙r＝- 0.473,p＝0.0183﹚、總膽固醇﹙r＝- 0.438,p＝0.0274﹚、低密度脂蛋白﹙r＝- 0.446,p＝0.0299﹚、及心血管疾病危險指數﹙r＝- 0.372,p＝0.0352﹚。 從結果得知，維生素C攝取與添加可以有效降低血漿脂質濃度和心血管疾病危險指數，而有預防心血管疾病發生的效果。

The objective of this study was to assess the relationship between ascorbic acid and the plasma lipid levels in health adult men. One hundred and ninety-nine men aging from 20-40 y participated in this study. All participants were non-smoking，non-drinking，and without taking any medication or vitamin-mineral supplementation. Subjects were randomly divided into eight groups 【group A：control；group B to H ：different amount of vitamin C （15、30、40、50、60、70、80 mg）】. Subjects of B to H received vitamin C supplementation for 4 weeks. Fasting blood samples were taken before and after supplementation. Three day dietary records were obtained from each subject one week before the study and each during the study. Subjects receiving vitamin C supplementation 50 mg or higher significantly decreased plasma triglyceride 【group E to H ， 7.35% ， 7.11% ， 8.16% ， and 7.66% ,respectively】，plasma total cholesterol 【group E to H，5.35% ， 6.18% ，6.59% ，and 5.61% ,respectively】，and plasma low-density lipoprotein（LDL） 【E to H group ，6.90% , 7.50% , 5.79% ， and 5.17% ,respectively】 concentrations. Ascorbic acid intake or supplementation had no effect on plasma high-density lipoprotein（HDL）or glucose concentration. Group E to H significantly decreased cardiovascular disease risk index after 4 weeks supplementation. Ascorbic acid supplementation significantly correlated with triglycerides﹙r＝- 0.473,p＝0.0183﹚,total cholesterol﹙r＝- 0.438,p＝0.0274﹚,LDL﹙r＝- 0.446,p＝0.0299﹚,cardiovascular disease risk index﹙r＝- 0.372,p＝0.0352﹚. Our results showed that ascorbic acid could lower plasma lipid levels and cardiovascular disease risk index. Ascorbic acid may prevent and lower cardiovascular disease risk index.