草本複方發酵液對血糖之調控

糖尿病是台灣十大死因之一，且與許多慢性病相關，對健康的傷害不容忽視。總酚類近期被認為有助於調控血糖且對抗氧化也有一定的功效。本研究在細胞試驗中以C2C12進行試驗，根據2-NBDG uptake結果顯示，草本複方發酵液有助於細胞對葡萄糖的攝取，且對胰島素作用途徑的IRS-1、PI3K與GLUT-4也助於提升其表現，表示草本複方發酵液有助於增加葡萄糖在細胞的攝取。在人體試驗中，以隨機分配將50位糖尿病前期受試者分為介入組與控制組，觀察每日上午空腹飲用30ml的草本複方發酵液是否有助於調控血糖。由結果顯示，介入12週後，受試者之舒張壓與收縮壓、空腹血糖值、胰島素、膽固醇、血漿過氧化物含量(TBARS)都有顯著改善。綜合上述，草本複方發酵液可促進細胞對葡萄糖的吸收且增加胰島素路徑因子的表現，同時具有調控血壓、血糖、血膽固醇與體內抗氧化反應之功效。

Diabetes is one of the top ten causes of death in Taiwan and is associated with many chronic diseases, posing a significant health threat. Recently, polyphenols have been recognized for their potential in regulating blood sugar and providing antioxidant benefits. In cellular experiments using C2C12 cells, results from the 2-NBDG uptake assay showed that the active herbal fermented liquid increased glucose uptake into the cells. It also positively influenced the expression of insulin signaling pathway components such as IRS-1, PI3K, and GLUT-4, indicating that the active herbal fermented liquid enhanced glucose uptake in cells. In human trials, participants with prediabetes were randomly assigned to either an intervention group or a control group to observe whether consuming 30ml of the active herbal fermented liquid every morning before meal helped to regulate blood sugar. Results indicated significant improvements in diastolic and systolic blood pressures, fasting blood glucose levels, insulin levels, cholesterol, and blood peroxide levels (TBARS) after 12 weeks of intervention. In summary, the active herbal fermented liquid can assist in glucose uptake by cells and enhance the expression of insulin pathway factors, while also providing benefits in regulating blood sugar, blood pressure, blood cholesterol, and oxidative reactions in the body.