Potential impact of <i>ADAM‐10</i> genetic variants with the clinical features of oral squamous cell carcinoma

<jats:title>Abstract</jats:title><jats:p>A disintegrin and metalloproteinase domain‐containing protein 10 (ADAM‐10) involves in the tumour progression, but the impacts of single‐nucleotide polymorphism (SNP) of <jats:italic>ADAM‐10</jats:italic> on oral squamous cell carcinoma (OSCC) remain unclear. The aim of this study was to investigate the influence of SNP of <jats:italic>ADAM‐10</jats:italic> on the clinical features of OSCC in male Taiwanese. Five loci of <jats:italic>ADAM‐10</jats:italic> SNPs including rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) and rs2054096 (A/T) were genotyped by TaqMan allelic discrimination in 1138 OSCC patients and 1199 non‐OSCC individuals. The <jats:italic>ADAM‐10</jats:italic> SNP rs2305421 GG (AOR: 1.399, 95% CI: 1.045–1.874, <jats:italic>p</jats:italic> = 0.024) and G allele (AOR: 1.170, 95% CI: 1.012–1.351, <jats:italic>p</jats:italic> = 0.034) illustrated a significantly higher genotypic frequencies in the OSCC group compared to the distribution of the <jats:italic>ADAM‐10</jats:italic> SNP rs2305421 AA wild type. In the subgroup analysis, the <jats:italic>ADAM‐10</jats:italic> SNP rs383902 TC+CC was significantly correlated to tumour size larger than T2 in betel quid chewer (AOR: 1.375, 95% CI: 1.010–1.872, <jats:italic>p</jats:italic> = 0.043), while the <jats:italic>ADAM‐10</jats:italic> SNP rs653765 CT+TT was significantly associated with tumour size larger than T2 in cigarette smoker (AOR: 1.346, 95% CI: 1.023–1.772, <jats:italic>p</jats:italic> = 0.034). The results from The Cancer Genome Atlas revealed highest <jats:italic>ADAM‐10</jats:italic> mRNA level in T2 stage of current smokers with head and neck squamous cell carcinoma (HNSCC). In conclusions, the <jats:italic>ADAM‐10</jats:italic> SNP rs2305421 G allele is associated with the presence of OSCC, and the <jats:italic>ADAM‐10</jats:italic> SNP rs383902 TC+CC and <jats:italic>ADAM‐10</jats:italic> SNP rs653765 CT+TT correlates to large tumour size in specific conditions.</jats:p>