Applying Taguchi Methodology to Optimize the Brain Image Quality of 128-Sliced CT

Injuries due to traffic accidents have been significant causes of death in Taiwan and traffic accidents have been most common in recent years. Brain computed tomography (CT) examinations can improve imaging quality and increase the value of an imaging diagnosis. The image quality of the brain gray/white matter was optimized using the Taguchi design with an indigenous poly-methylmethacrylate (PMMA) slit gauge to imitate the adult brain and solid water phantoms. The two gauges without coating contrast media were located inside the center of a plate to simulate the brain and scanned to obtain images for further analysis. Five major parameters—CT slice thickness, milliampere-seconds, current voltage, filter type, and field of view—were optimized. Analysis of variance was used to determine individual interactions among all control parameters. The optimal experimental acquisition/settings were: slice thickness 2.5 mm, 300 mAs, 140 kVp, smooth filter, and FOV 200 mm2. Signal-to-noise was improved by 106% (p < 0.001) over a routine examination. The effective dose (HE) is approximately 1.33 mSv. Further clinical verification and the image quality of the ACR 464 head phantom is also discussed.