Leptin、 Ghrelin 、Glutathione以及oxidation在於第二型糖尿病人與正常人兩者血液間之比較

因此本實驗收集了40位第二型糖尿患者及15位正常人血液樣本，利用商業檢驗套組來分析，以比較第二型糖尿病人與正常人兩者血液間之Leptin、Ghrelin、 麩胱苷肽(Glutathione； GSH)濃度，以及oxidation情形。本實驗結果為：在第二型糖尿病女性病人其Leptin濃度比男性病人高亦比正常女性Leptin濃度高，都有統計學上的顯著差異(P<0.05)；在Ghrelin濃度則是男性糖尿病人Ghrelin濃度較正常人高，女性糖尿病人Ghrelin濃度比正常人較低，不論男女糖尿病人與正常人相比皆無統計學上的顯著差異(P<0.05)；男性糖尿病人GSH濃度比正常人高，並且兩者相比有統計學上的顯著差異(P<0.05)；另外糖尿病人不論男女其MDA值及HbA1c濃度皆比正常人高，並且有統計學上的顯著差異(P<0.05)。顯示出糖尿病人確實比正常人有較高的氧化及醣化傷害壓力存在著，因此在減緩糖尿病相關心血管併發症的發生是值得注意的。

Diabetes is one of the major chronic diseases in Taiwan. The impact of leptin and ghrelin upon diabetic progression has been paid attention. This study included 40 type II diabetic patients and 15 healthy controls. Blood levels of leptin, ghrelin, GSH and lipid oxidation were analyzed. Results showed that diabetic female had significantly higher leptin than diabetic male (P<0.05), diabetic male had significantly higher ghrelin than diabetic female (P<0.05). Diabetic patients has greater level of GSH than healthy control (P<0.05). Both oxidation level, determined as MDA, and HbAlc level were significantly greater in diabetic patients (P<0.05). These results indicated that the influence of leptin, ghrelin and HbAlc in diabetic patients needs to be paid more attention.