CREB-binding protein expression and the correlation with clinical aspects of oral squamous cell carcinoma

The CREB-binding protein (CBP) is a member of the histone acetyltransferase family of transcriptional coactivators that regulate the chromosomal infrastructure and mediate the combination of transcription factors and DNA. However, the clinical significance of CBP expression in oral squamous cell carcinoma (OSCC) and its correlation with patients' prognoses remain unclear. Materials and methods: CBP expression in 276 patients with OSCC was detected using tissue microarrays, and the associations between nuclear CBP expression and the clinical parameters of OSCC patients were evaluated. Results: Nuclear CBP expression was observed in 182 patients (68.2%), and high nuclear CBP expression was associated with a more receded clinical stage (P = 0.031) and smaller tumor size (P = 0.007) but not associated with positive lymph node metastasis or distal metastasis. Conclusion: Our results revealed that the loss of CBP nuclear expression in OSCC samples can predict the progression of OSCC patients in Taiwan.