台灣巴瑞特氏患者的臨床與食道黏膜生物標記表現

巴瑞特氏食道是下食道鱗狀上皮被柱狀上皮取代的一種病變，其重要性在於有較高的機會變成食道柱狀上皮癌，有關於台灣本土性巴瑞特氏食道的資料甚少。本研究共採兩部份，第一部份為回溯性納入台灣中部某一醫學中心接受高階健康檢查中心檢查之族群，期限是2006年至2009年，共有7712人納入，其中巴瑞特氏食道者有95人。第二部份為前瞻性納入台灣中部某一醫學中心肝膽腸胃科門診確診為巴瑞特氏食道病患，期限是2012年至2014年，共納入152人。本研究結果包含以下發現：（1）巴瑞特氏食道族群有顯著較高比例符合代謝症候群診斷；（2）體重過重或肥胖與巴瑞特氏食道並無顯著關係性存在；（3）巴瑞特氏食道大多為短型，佔93.4%；（4）男性巴瑞特氏食道相較於女性擁有較嚴重的內視鏡表現以及病理發現；（5）伴隨化生不良組織之巴瑞特氏食道皆屬於短型，且有較高的喝酒與抽菸比例；（6）巴瑞特氏食道族群生活品質影響因素為焦慮、憂鬱以及典型胃食道逆流症狀嚴重度；（7）TGF-β值或是PAR-2值在巴瑞特氏食道相比於食道中段與胃底部有顯著意義的下降。本研究探討台灣華人患有巴瑞特氏食道者的臨床相關表現，對於早期診斷此疾病有所助益。

Barrett''s esophagus (BE) is defined as the abnormal transformation of the squamous epithelium, and it was considered as a precursor of esophageal adenocarcinoma, but the data in Taiwan is limited. This study is composed with two parts. The first part is designed as retrospectively collecting the individuals who visited a medical screening unit at a center hospital in Taiwan from 2006 to 2009. Totally 7712 cases are enrolled, and 95 subjects with BE. The secondary parts is designed as prospectively collecting the individuals with BE at a center hospital in Taiwan from 2012 to 2014, and 152 subjects are enrolled.The results of this study show：（1）a great risk of concurrent metablolic syndrome in the individuals with BE；（2）the association of BE and obesity is not significant；（3）93.4% subjects with BE are belonged to short-segument；（4）Male BE cases are prone to have more severity of both endoscopic and pathologic presentations；（5）The subjects with dysplatic BE tissue are belong to short-segument, and having a higher ratio of alcohol drinking and smoking；（6）the quality of life in BE subjects is association with presentations of anxiety, depression and reflux symptoms；（7）the expressions of TGF-β and PAR-2 are lower in the tissue of BE.. The conclusions of this study provide new insights of BE in the Taiwan Chinese population.