脂肪攝取量與性別對基因甲基化的交互作用

異(p-value=0.0145)。後續行分層分析，發現女性的高脂肪攝取量與cg022632260有正相關 (β=0.00597; 95%CI=0.0010061-0.01133)，而趨勢分析有統計學上的意義(p-value=0.0283)。總結，高脂肪飲食的女性有較高的cg02263260位點的甲基化，趨勢分析有意義。我們猜測高脂肪飲食對於CDH13 cg02263260位點的甲基化的影響在性別上有所不同。女性且較高脂肪飲食者會有較高的CDH13 cg02263260位點的甲基化。

Cadherin 13 (CDH13) is a tumor suppressor gene. DNA methylation of CDH13 is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Taiwanese adults. Data of 870 eligible participants (430 men and 440 women) aged 30-70 years were obtained from the Taiwan Biobank (TWB) database. The association of dietary fat and sex with CDH13 cg02263260 methylation was determined using multiple linear regression. The association between sex and cg02263260 methylation was significant: beta‐coefficient (β) = 0.00532; 95% confidence interval (CI) = 0.00195–0.00868. Moreover, the interaction between sex and dietary fat on cg02263260 methylation was significant (P‐value = 0.0145). After stratification by sex, the association of dietary fat with cg02263260 methylation was significant only in women. Specifically, high dietary fat was positively associated with cg02263260 methylation in women (β = 0.00597; 95% CI = 0.00061–0.01133) and the test for trend was significant (P‐value = 0.0283). High fat intake was significantly associated with higher cg02263260 methylation in women and the test for trend was significant. These findings suggest that the association of fat intake and CDH13 cg02263260 might vary by sex and CDH13 cg02263260 methylation levels in women might increase as fat intake increases.