Component effects of bioactive glass on corrosion resistance and in vitro biological properties of apatite-matrix coatings

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<jats:title>BACKGROUND:</jats:title>
<jats:p>Surface modification of metallic implants is critical for improving the clinical performance of the dental and orthopedic devices. Bioactive glasses exhibit different levels of cellular function and physicochemical behavior; however, there have been few previous studies on the effect of constituents of the bioactive glasses on the in vitro osteogenic activity and corrosion resistance of apatite-based coatings.</jats:p>
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<jats:title>OBJECTIVE:</jats:title>
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The objective of this work was to investigate the effect of SiO
<jats:sub>2</jats:sub>
, CaO, Na
<jats:sub>2</jats:sub>
O, and P
<jats:sub>2</jats:sub>
O
<jats:sub>5</jats:sub>
on plasma-sprayed apatite coatings on Ti alloy substrates for tailoring the properties of implants making them suitable for clinical applications.
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<jats:title>METHODS:</jats:title>
<jats:p>The corrosion potential and corrosion current of various coatings in simulated body fluid (SBF) were examined. MG63 cell proliferation, differentiation, and mineralization of plasma-sprayed apatite-matrix coatings were evaluated.</jats:p>
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<jats:title>RESULTS:</jats:title>
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The SiO
<jats:sub>2</jats:sub>
and CaO-containing HA (HSC) coating had a higher corrosion potential than the other three coatings, while SiO
<jats:sub>2</jats:sub>
-containing HA (HS) coating displayed the highest corrosion current among all coatings. The effect of the oxides on cell functions followed the order SiO
<jats:sub>2</jats:sub>
> CaO > P
<jats:sub>2</jats:sub>
O
<jats:sub>5</jats:sub>
> Na
<jats:sub>2</jats:sub>
O in terms of cell attachment, proliferation, differentiation, and mineralization.
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<jats:sec>
<jats:title>CONCLUSIONS:</jats:title>
<jats:p>The flexibility in oxide doping may allow for the tunable biological properties and corrosion-resistant ability of the apatite coatings.</jats:p>
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