Skin diseases caused by factors from the environment

Members of the order Diptera, the family Culicidae, mosquitoes are vectors for the transmission of many diseases worldwide. There are over 3000 different species of mosquitoes, which grouped into more than 40 genera (Garcia Diagnostic Medical Parasitology 682, 2007; Peng and Simons Int Arch Allergy Immunol 133:198–209, 2004). Although many mosquito bites produce only mild and transient cutaneous reactions, more severe allergic reaction as hypersensitivity could also happen. Hypersensitivity to mosquito bites is a rare disease characterized by intense local skin reactions with general symptoms, such as high fever and regional lymphadenopathy after mosquito bites. Chronic active Epstein–Barr virus (EBV) infection and NK cell lymphoproliferative disease have been reported in hypersensitivity to mosquito bite patients.