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心導管手術病人其手術前後周邊血液中基質金屬蛋白水解變化分析
Journal Volume
中山醫學雜誌 v14 n.1 p37-43
Date Issued
2010-07-28T08:57:04Z
Abstract
基質金屬蛋白水解（MMP）在心臟血管疾病中扮演著非常重要的角色。在之前的文獻報導指出：粥狀動脈硬化病人的周邊血液中MMP-2和MMP-9的活性會昇高。因此，我們想探討當粥狀動脈硬化病人在接受心導管手術後，其周邊血液中MMP-2和MMP-9的活性變化情形。本實驗收集心導管手術病人，其手術前及手術後二十四小時的周邊血液，利用gelatin zymography的方法進行分析，觀察MMP-2及MMP-9的活性表現。我們以動脈狹窄的程度作為依據，將病人分成重度狹窄及重度狹窄並放置支架的病人。結果發現重度狹窄的病人，其MMP-9的活性在手術後有明顯的下降，至於動脈重度狹窄並放置支架的病人，其MMP-9的活性在手術前後並沒有明顯的差異。因此，我們認為粥狀動脈硬化病人在接受心導管手術後，其MMP-9的活性會受到動脈狹窄程度不同及放置支架與否而改變，也許我們可以藉著MMP-9活性的變化來當作輔助心導管手術前及心導管手術後，再度狹窄的評估工具。
Matrix metalloproteinase (MMP) activity is related to atherosclerosis and vascular remodeling. In this report, we studied 50 patients with angina pectoris who underwent elective PTCA. They were divided into Group I (POBA group) and Group II (stent group). In Group I, there were no significant changes in serum MMP-2 activity; MMP-9 activity decreased 24 hours after the procedure. In Group II, no significant changes in either MMP-2 or MMP-9 occurred. These findings suggest that changes in MMP-9 may be related to lumen dilatation and stent placement. Future studies are needed to clarify this relationship.
Matrix metalloproteinase (MMP) activity is related to atherosclerosis and vascular remodeling. In this report, we studied 50 patients with angina pectoris who underwent elective PTCA. They were divided into Group I (POBA group) and Group II (stent group). In Group I, there were no significant changes in serum MMP-2 activity; MMP-9 activity decreased 24 hours after the procedure. In Group II, no significant changes in either MMP-2 or MMP-9 occurred. These findings suggest that changes in MMP-9 may be related to lumen dilatation and stent placement. Future studies are needed to clarify this relationship.