武漢地區孕婦德國麻疹感染之血清學研究

To understand the infection rate of maternal rubella (German measles) among pregnant women living in the Wu-Han area of the Hu-Bei Province, a large-scaled survey was conducted by using the enzyme-linked immunosorbant assay (ELISA). A group of 617 normal, healthy women in the first three to six months of their pregnancy were screened. Our results indicated that 73.1%(451 in 617)were IgM positive. When compared the percentage of the IgG-negative obtaining in this study to those of similar surveys conducted in other large cities. We found that IgG-negative rate in pregant women in the Wu-Han area are much higher than other areas, suggesting that more pregnant women are lack of the immunity to rubella infection in Wu-Han area. Rubella infection, especially occurred in the early pregnancy, it is belived to associate with spontaneous abortion, premature birth and still birth as congenital anomalies. Therefore, it is considerably important to evaluate the immunity status of pregnant women to prevent the abnormal birth. Since rubella viral infection usually elicits a life-time immunity, therefore, previous infection or qcquired immunity viavaccine immunization before pregnancy could effectively prevent to deliver babies with congenital anomalis. Based on our findings, we highly recommend the vaccination against measles, mupmps, and rubella (The MMR vaccine) should be provided to children of both sexes older than 15 months, students in primary school and those of ninth graders in order to prevent the occurance of congenitally abnormal babies in their pregnancies.