B型肝炎病毒子宮內感染之調查研究

為進一步瞭解，孕婦B型肝炎病毒子宮內感染的情形 ，以作為B型肝炎帶原母親將病毒傳染給胎兒或新生兒之預防決策依據。
抽取273位孕婦之靜脈血，以酵素免疫分析法(ELISA) ，篩檢HBsAg，HBeAg，Anti-HBs，Anti-HBe and Anti-HBc標誌作為初篩。對HBsAg單陽性或HBsAg，HBeAg雙陽性的母親，所生的所有嬰兒，在出生後二十四小時之內，出生後一個月，六個月，各抽取靜脈血，分離血清，以放射免疫檢定法(Ratio-immunoassay)，連續三次HBsAg篩檢。
273位健康孕婦，抽血檢驗結果，發現HBsAg陽性者有27位、佔9.89%，其中HBsAg單陽性者有9位、佔3.3%，另18位為HBsAg，HBeAg雙陽性佔6.59%，Anti-HBs陽性者有2位、佔0.73%，Anti-HBe陽性者有13位、佔4.76%，Anti-HBc陽性者有14位、佔5.13%。9位HBsAg單陽性母親，所生的嬰兒從出生到六個月，連續三次HBsAg篩檢，結果到六個月時發現有3位、佔16.67%嬰兒HBsAg陽性反應，此3為嬰兒在所有273位被篩檢HBsAg帶原者佔1.1%。
建議結婚夫婦在婚前、孕前獲妊娠早期做B型肝炎病毒檢查。同時也建議對具有B型肝炎表面抗原(HBsAg)陽性及B型肝炎病毒e抗原(HBeAg)陽性帶原母親所生的嬰兒，在出生二十四小時內給予B型肝炎免疫球蛋白(hepatitis B immunzation) 然後再給予B型肝炎疫苗注射。
To understand the intrauterine hepatitis B virus infection among pregnant women, and to determine the need of establishing programs for prevention of maternal transmission.
Venous blood samples of 273 pregnant women were collected and screened for HBsAg, HBeAg, Anti-HBe and Anti-HBc using ELISA method. All infants born to mothers who were positive for HBsAg and HBeAg were screened for HBsAg using the radioimmunoassay method at birth, 1 month and 6 months after birth.
Twenty-seven apparently healthy pregnant women (9.89%) were HBsAg-positive. Among Those, 9(3.3%) were HBsAg-positive along and 18(6.59%) were positive for HBsAg and HBeAg. Two of the women were Anti-HBs-positive(0.73%), 13(4.76%) were Anti-HBe-positive, and 14(5.13%) were Anti-HBc-positive. Nine infants born to mothers positive for HBsAg alone showed negative of HBsAg and HBeAg, 3(16.17%) were HBsAg seropositive six months after their births. An overall rate of HBsAg carrier was estimated as 1.1%(3/273) in infants born to all prenant women studied.
Couples are recommended to receive HBV test before marriage and pregnancy, as well as at their early pregnancies. Immunization of infants born to HBsAg/HBeAg-positive mothers with hepatitis B immunoglobulin within 24 hours after delivery and with hepatitis B vaccine later were suggested.