苦茶油調節血脂及腸道功能之研究

苦茶油中富含多種具有生物活性的多酚類，且具有東方橄欖油的美稱。本研究擬探討給予血膽固醇偏高之受試者苦茶油，對於血膽固醇與腸胃道蠕動功能之改善。 本試驗共計30位之受試者（男性9位，女性21位）全程參與，採隨機單盲、安慰劑對照設計。實驗期間共10週(8週試驗期加2週追蹤期)，分為兩組，一組飲用8週苦茶油每天早晨空腹10 mL，另一組飲用安慰劑大豆沙拉油8週每天早晨空腹10 mL。試驗期間，分別測量體位、糞便、血液生化值、小腸排空速度、飲食紀錄及問卷。結果顯示，飲用8週後，可有效降低血膽固醇且減少腫瘤壞死因子(TNF-α)，另外，小腸攝影檢測結果也顯示，飲用苦茶油可以改善小腸排空的速率，顯著縮短腸道中食糜通過之時間，且糞便含水率及糞便型態之軟條狀也有顯著上升，此外，體內總抗氧化力與血漿多酚化合物含量皆顯著增加，血漿脂質過氧化物含量則顯著降低，LDL氧化耐受性顯著提高。由本研究可以得知，以苦茶油介入後，確實具有降低血膽固醇、降血壓、抗發炎、改善腸道蠕動及增加抗氧化能力。

This study aims to evaluate the effects of camellia oil supplementation on improving blood cholesterol levels and gastrointestinal motility in subjects with toward higher blood cholesterol.Totally of 30 participants (9 males and 21 females) completed the trial, which was conducted as a randomized, single-blind, placebo-controlled study.The experimental period was eight weeks extra two weeks were follow up period .All participants were divided into two groups, one group received camellia oil experiment and the other received a soybean oil. Body composition, stool analysis, blood biochemistry, small intestine emptying rate, dietary records, and questionnaires were done in this study. Results showed that after 8 weeks of intervention blood cholesterol levels and tumor necrosis factor-alpha (TNF-α) were significantly reduced. Additionally, small intestine imaging indicated that camellia oil improved the small intestine emptying rate, significantly reducing the time for chyme to pass through the intestine. Furthermore, stool water content increased significantly. Total antioxidant capacity and plasma polyphenol levels were significantly increased, while plasma lipid peroxide levels were markedly reduced.The oxidative resistance of LDL was also significantly enhanced. In conclusion, this study indicated that camellia oil supplementation effectively lowered blood cholesterol and blood pressure, exerts anti-inflammatory effects, improved intestinal motility, and increased antioxidant capacity.