中藥方劑--補中益氣湯--抗老年痴呆症於S.A.M.之研究

補中益氣湯係收載於元朝李東垣「脾胃論」之中藥方劑，由黃耆、甘草、人參、當歸、陳皮、升麻、柴胡及白朮等組成。為治脾胃氣虛、中氣下陷之要方。中醫所指的「氣」即是現今西醫所稱的「循環系統」，若循環系統正常則會促進腦部血液循環的順暢，因此有助於記憶力的增強，同時亦可減緩老化的進行。針對此一觀點。我們使用自然老化促進型之小白鼠(SAM: Senescence Accelerated Mouse)的Dull、P唌BR絞琱呰CR系小白鼠(Mouse)為實驗之對象來探討補中益氣湯減緩老化作用及改善記憶力之效果。以口服給藥法投予500mg/kg之補中益氣湯，進行(1)抗疲勞強制游泳之試驗。(2)八方迷宮記憶力之試驗。(3)神經肌肉協調度之試驗。(4)藥物對小白鼠腦內單胺(Monoamine)含量變化之影響。對正常之ICR系小委鼠與老化促進型之小白鼠(SAM)加以比較。由實驗結果得知：連續口服補中益氣湯7天的SAM系小白鼠，於游泳試驗中得知自游泳開始至後肢靜止不動的時間呈現出現有意義的延長(P<0.01)。連續口服500mg/kg之補中益氣湯達14天之實驗群動物對八方迷宮記憶力有顯著的改善(P<0.01)。於神經肌肉協調度的Rota Rod Test中，強迫跑步的時間呈現出大幅度有意義(P<0.01)的延長。連續口服500 mg/kg之補中益氣湯達21天之SAM系及ICR系小白鼠其腦中單胺(Monoamine)之5-HT(Serotonin)及NA(Nor-adrenaline)的含量呈現出有意義(P<0.05)的變化，由此一研究的結果使我們得知：補中益氣湯具有改善生理之老化現象及增強記憶力的效果，而此一效果與補中益氣湯影響腦內單胺(Monoamine)含量的變化有顯著的關連性存在。
In this study is to make use of the S.A.M. (Sensecence Accelerated Mouse). Which take Chinese Tradition Prescription-BuZhong YiQiTang (B.Z.Y.Q.T.)to observe the effect on aging prevention and memory obstruction. Male aged 10 weeks of Dull, P/8 and R/1 of S.A.M. and ICR mouse were adopted in this study. By taking the B.Z.Y.Q.T. for 4 weeks (p.o.), the experiment will proceed for (1)Reference memory total errors in the radial maze task. (2)Forced swimming test. (3)Rotar Rod test, B.Z.Y.Q.T. were administrated by p.o./day dosage of 250mg/kg and 500 mg/kg. The comparison group will be taken with 0.9% NaCl. From the result of our experiment the mice which administrate 250mg/kg B.Z.Y.Q.T. showed significant improvement on the memory obstruction. After taking continuously 2 weeks of B.Z.Y.Q.T. The time on forced swimming test will be extended (P<0.01), and which will have and obvious improvement on sports effect by Rotar Rod test. Viewing from above mentioned face. We believe that B.Z.Y.Q.T. has and effect on improvement of aging and also increase the function on memory. Therefore, it is worthy of continuous research.