Transcriptional Suppression of miR-7 by MTA2 Induces Sp1-Mediated KLK10 Expression and Metastasis of Cervical Cancer

Journal
Molecular Therapy Nucleic Acids
Date Issued
2020-06-05
Author(s)
DOI
URI
Abstract
In vitro and in vivo studies revealed that knockdown of MTA2 inhibits metastasis of cervical cancer through induction of miR-7 targeting Sp1/KLK10 expression. These finding provide novel molecular mechanistic insight on the MTA2/miR-7/Sp1/KLK10 axis and its potential therapeutic target in cervical cancer.
Type
journal article