An Interpretable Three-Dimensional Artificial Intelligence Model for Computer-Aided Diagnosis of Lung Nodules in Computed Tomography Images

<jats:p>Lung cancer is typically classified into small-cell carcinoma and non-small-cell carcinoma. Non-small-cell carcinoma accounts for approximately 85% of all lung cancers. Low-dose chest computed tomography (CT) can quickly and non-invasively diagnose lung cancer. In the era of deep learning, an artificial intelligence (AI) computer-aided diagnosis system can be developed for the automatic recognition of CT images of patients, creating a new form of intelligent medical service. For many years, lung cancer has been the leading cause of cancer-related deaths in Taiwan, with smoking and air pollution increasing the likelihood of developing the disease. The incidence of lung adenocarcinoma in never-smoking women has also increased significantly in recent years, resulting in an important public health problem. Early detection of lung cancer and prompt treatment can help reduce the mortality rate of patients with lung cancer. In this study, an improved 3D interpretable hierarchical semantic convolutional neural network named HSNet was developed and validated for the automatic diagnosis of lung cancer based on a collection of lung nodule images. The interpretable AI model proposed in this study, with different training strategies and adjustment of model parameters, such as cyclic learning rate and random weight averaging, demonstrated better diagnostic performance than the previous literature, with results of a four-fold cross-validation procedure showing calcification: 0.9873 ± 0.006, margin: 0.9207 ± 0.009, subtlety: 0.9026 ± 0.014, texture: 0.9685 ± 0.006, sphericity: 0.8652 ± 0.021, and malignancy: 0.9685 ± 0.006.</jats:p>