Dietary potato peel extract reduces the toxicity of cholesterol oxidation products in rats

We determined the polyphenolic profiles of the potato peel by HPLC. To elucidate the effect of potato peel extract (PPE) on the toxicity of cholesterol oxidation products (COPs) in rats, a synthetic polyphenolic mixture was prepared, mimicking the composition of PPE. Six groups were treated with a control diet, an oxidized cholesterol diet, a PPE diet, an oxidized cholesterol plus PPE diet, and various doses (1–3%) of the PPE diet. After treatment, significantly increased liver glutathione and trolox equivalent antioxidant capacity levels; superoxide dismutase, catalase, and glutathione peroxidase activities; and mRNA expression were observed in the rats treated with 2% and 3% doses of the PPE diet and significantly decreased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, and COPs levels were observed compared with the control rats. These results demonstrated the PPE diet reduction in the long-term toxicity of COPs was significant in rats.