The relevance of serum anti-Müllerian hormone levels, chronological age and embryo quality to the outcome of assisted reproduction technology cycles

Background Anti-Müllerian hormone (AMH) has been reported to be intimately correlated topregnancy outcome in IVF cycles, although some conflicting results also exist in themedical literature. This study intended to assess the capability of combining of AMH andembryo quality as predictors of pregnancy outcome.MethodsA prospective cohort of 404 IVF/ICSI cycles was investigated. In order to evaluatethe predictive value for pregnancy in IVF cycles based on chronologic age, basal FSHlevel, basal AMH level, and antral follicle count (AFC), together with certain embryorelatedparameters, ROC curve analysis and logistic regression model were utilized. ResultsThe basal serum AMH level (odds ratio: 1.222~1.978) and chronologic age (oddsratio: 0.637~0.929) were the major predictive factors of pregnancy for women older than35 years of age. Regarding the young age group, the number of transferred embryos(odds ratio: 1.199~1.745) and the rate of good embryos (odds ratio: 1.149~7.510) werethe main predictors of successful treatment by IVF.ConclusionThe basal serum AMH level is a useful tool to provide a realistic probability ofpregnancy for counseling purposes, especially for women older than 35 years of age.