臺灣2008-2015年出生世代肺炎鏈球菌結合型疫苗接種對侵襲性肺炎鏈球菌感染症的影響

背景：我國自2009年7月逐步擴大幼兒公費接種對象範圍，至2015年將13價肺炎鏈球菌結合型疫苗(PCV13)納入現行兒童預防接種時程疫苗。我們研究肺炎鏈球菌結合型疫苗接種對侵襲性肺炎鏈球菌感染症(IPD)的影響。方法：我們統計2008年至2015年出生世代在2008年1月1日至2016年6月30日間肺炎鏈球菌結合型疫苗的接種紀錄，並與同區間的通報IPD確定病例進行比對分析。結果：2008年至2015年出生世代有91.38%曾經接種過任一種肺炎鏈球菌結合型疫苗，有718例確定侵襲性肺炎鏈球菌感染症(IPD)，678例檢出血清型別(94.43%)，40例無檢出血清型別(5.57%)。有接種PCV13及任一種PCV罹患IPD的風險是没有接種的0.74及0.64倍，有顯著保護意義。結論：肺炎鏈球菌結合型疫苗接種涵蓋率高、普及性強且疫苗免疫保護成效好。更密集更多點線面的監測，以因應因血清型別的變化而可能需修正的相關防治措施。

Background: Since July 2009, we have gradually expanded the range of inoculated vaccination for children, and the 13-Valent Pneumococcal conjugate vaccine (PCV13) is included in the vaccination schedule for children in 2015. We investigated the effect of pneumococcal conjugate vaccination on invasive pneumococcal disease (IPD).Methods：Between January 1, 2008 and June 30, 2016, we counted the inoculation record of the pneumococcal conjugate vaccine from birth in 2008 to 2015 and the IPD cases for comparison analysis.Results：There were 91.38% of the 2008 to 2015 birth generation had been vaccinated with any kind of pneumococcal conjugate vaccine, there were 718 cases of invasive pneumococcal disease (IPD), serotype detected 678 cases (94.43%), 40 cases without detectable serotype (5.57%). The risk of developing IPD was inoculated with PCV13 and any type of PCV was 0.74 and 0.64 times without vaccination, significant protection of meaning.Conclusion：Pneumococcal conjugate vaccine vaccination covers high popularity and strong and good vaccine protection effect. More intensive and more monitoring points to be due to changes in the type of serum may need to amend the relevant control measures.