人類微小病毒B19感染與癌症相關性之研究

研究顯示人類微小病毒B19 (B19V)感染與許多癌症相關，像睪丸癌、血癌、結腸癌和甲狀腺癌。2018年全球癌症統計數據，發病率與死亡率，男性肺癌第一，女性乳腺癌第一。但是目前B19病毒感染在肺癌與乳癌的影響與流行率仍然並不清楚。因此本論文探討B19病毒感染與肺癌及乳癌之間的相關性。研究樣本包括有62名肺癌患者，89名乳癌患者和41名健康對照者。研究分析血清樣本B19 IgM/IgG/B19-VP1u IgG抗體與B19 DNA之表現情形。結果顯示在62位肺癌患者中，B19 IgM (1.61%)，B19 IgG (17.74%)，B19-VP1u IgG (12.90%)；在89位乳癌患者中，B19 IgM (0%)，B19 IgG (13.48%)，B19-VP1u IgG (12.36%)；41位健康對照者中，B19 IgM (2.4%)，B19 IgG (12.20%)，B19-VP1u IgG (7.31%)。所有檢體皆無檢測出B19 DNA。綜合以上結果統計分析顯示，人類微小病毒B19感染與肺癌和乳癌之間並沒有顯著相關性。

Studies have shown that human parvovirus B19 (B19V) infection is associated with many cancers，such as testicular cancer，blood cancer，colon cancer，and thyroid cancer. Global cancer statistics 2018 reported that，morbidity and mortality，lung cancer is first one among male，breast cancer first among female. However，the impact and prevalence of B19 virus infection in lung cancer and breast cancer is still unclear. Therefore，this paper explores the correlation between B19 virus infection and lung cancer and breast cancer. The study sample included 62 lung cancer patients，89 breast cancer patients，and 41 healthy controls. The study analyzed the expression of serum samples B19 IgM/IgG/B19-VP1u IgG antibody and B19 DNA. The results showed that among the 62 lung cancer patients，B19 IgM (1.61%)，B19 IgG (17.74%)，B19-VP1u IgG (12.9%); among 89 breast cancer patients，B19 IgM (0%)，B19 IgG (13.48) %)，B19-VP1u IgG (12.36%); 41 healthy controls，B19 IgM (2.4%)，B19 IgG (12.20%)，B19-VP1u IgG (7.31%). No B19 DNA was detected in all samples. Taken together，the above results showed that there was no significant correlation between B19V infection and lung cancer and breast cancer.