2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/37438The data shown by Milich et al.(1997) and this lab.have suggested that there is a cross-regulated Th1 / Th 2 cell balance exist during HBV infection.It was shown that IFN-α，which is the most effective treatment for chronic HBV infection，appears capable of altering the Th 1 / Th 2 cell balance toward the Th 1 subset. And this balance is close related to disease progression. It was known that the anti-HBc IgG subclasses patterns were different in cured patients and chronic carriers. Moreover, HBcAg preferentially, but not exclusively，elicits Th 1-like cells and HBeAg preferentially，but not exclusively，elicits Th 2-like cells. Hence，this study was designed to investigate the anti-HBe IgG subclasses patterns in cured patients and chronic carriers and to study the change of cytokines and the patterns of anti-HBs，anti-HBc，and anti-HBe IgG subclasses in IFN-α treated patients.由於先前Milich et al.(1997)及本人的研究顯示，在HBV感 染時，體內之Th1與Th2之間有互相調節之平衡關係，可藉由 細胞激素，如IFN－α加以改變，使其偏向Th1進行，行而此 種關係與疾病之進展有關，目前已知在抗原清除族群及帶原 者其體內anti-HBs之IgG次型抗體類型不同，而HBcAg本身又 與Th 1之進行有正向關聯，HBeAg 則與Th 2之進行有正向相 關，因此本計劃擬進一步探討在抗原清除族群及帶原者其體 內anti-HBe之IgG次型抗體類型，並另以接受IFN－α治療之 病人，其體內細胞激素之類型是否伴隨anti-HBs、anti-HBc 、anti-HBe IgG 次型抗體類型之改變，來進一步了解IgG次 型抗體與Th 1 / Th 2之關係。Project