TAI-CHEN LIN2026-10-162026-10-162025-10-01Pure ID: 15097501Pure UUID: 19293829-3f23-4eef-9447-ce511152238e10.1016/j.jds.2025.06.018https://www.scopus.com/pages/publications/105010702902https://scholars.csmu.edu.tw/handle/123456789/33893Favorable outcomes have been reported with periodontal regeneration therapies using dental lasers for blood clot formation. Herein, we presented the clinical and radiographic outcomes of carbon dioxide laser-assisted bone regenerative therapy (LBRT) in periodontology. A 60-year-old man presented with mobility in teeth 43 and 44. Accordingly, the extraction of tooth 44 and periodontal regeneration using carbon dioxide-LBRT around tooth 43 were planned. After thorough debridement, enamel matrix derivative and carbonated apatite (CA) were applied to the root surface and bone defects, respectively. Thereafter, the filled blood-mixed CA was irradiated using a carbon dioxide laser to accelerate blood clot formation for stabilizing the bone graft. At the 13-month follow-up, significant improvements in clinical parameters were observed, indicating substantial bone regeneration. In this patient, the excellent clinical and radiographic healing demonstrated the efficacy of carbon dioxide-LBRT for periodontal regeneration. Blood clot formation using a carbon dioxide laser may lead to favorable outcomes.4enjournal article