YI-SUN YANGSHUN-FA YANGCHIN-FENG TSAI2026-10-162026-10-162019-01-01Pure ID: 15248077Pure UUID: a301e9a3-91ca-42cb-a7e7-09861382852610.1177/0300060519839519https://www.scopus.com/pages/publications/85078693313https://scholars.csmu.edu.tw/handle/123456789/26855Objective: Coronary artery disease (CAD) is the principal cause of mortality and morbidity worldwide. Studies have provided controversial results regarding whether variations in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) are risk factors for CAD. In this study, we evaluated the risk factors associated with PSCK9 genotypes and CAD in the Taiwanese population. Methods: A total of 501 patients diagnosed with CAD by angiography and 334 CAD-free controls were recruited. Two single nucleotide polymorphisms of PSCK9 (rs505151 and rs529787) were genotyped. Results: The prevalence of a positive family history for CAD was significantly higher in individuals carrying the AG + GG genotype of the PSCK9 rs505151 polymorphism. Among CAD patients with a positive family history, the prevalence of diabetes mellitus was significantly higher in those carrying the AG + GG genotype of the PSCK9 rs505151 polymorphism (73.3%) than in those carrying the AA genotype (39.2%). Conclusion: In CAD patients, the AG genotype of PSCK9 rs505151 is associated with diabetes and a positive family history of CAD.enjournal article