2026-09-302026-09-30https://scholars.csmu.edu.tw/handle/123456789/19658Recently, high thymidylate synthase (TS) expression has been demonstrated as major factor for pemetrexed resistance. Therefore, a clear characterization of the mechanisms to overcome pemetrexed-re...(詳)目前認為是因為胸苷酸合成酶(TS)蛋白質高量造成肺癌對愛寧達產生抗藥性，可是對如何解決愛寧達產生之抗藥性並無相關的研究。因此尋找有效的第二線化療用藥來對付具有愛寧達抗藥性之肺癌就顯得非常需要。...(詳)愛寧達抗藥性Pemetrexed resistance胸苷酸合成酶Thymidylate synthase上皮-間質轉化Epithelial–mesenchymal transitionERK蛋白激酶E-cadherin 基因轉錄抑制因子ZEB1長春花生物鹼Vinca alkaloidsPemetrexed resistanceThymidylate synthaseEpithelial–mesenchymal transitionERKZEB1Vinca alkaloidsProject