2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38543Despite the rapid progress of new imaging modalities such as CT, MRI and ultrasound, the angiography still plays the crucial role in the diagnosis of vascular lesions. In general, the conventional digital subtraction angiography (DSA) modalities utilized an image intensify tube as a detector to acquire image. Recently, the new imaging system for angiography, cone beam CT angiography system, was developed due to the mature technology of cone beam CT reconstruction and the well development of flat panel detector. The flat panel detector provides higher spatial resolution and S/N ratio than the image intensify tube. Furthermore, it combined with cone beam CT techniques can provide 3D blood vessel images. In addition, this new imaging system also could provide the real-time 3D CT anatomical image acquisition simultaneously. If integrated these two image data, it could show the 3D vessel orientation and anatomical information in the same image space. By this technology, the 3D images integration provides a better understanding in the complex vascular pathologies and localization with other important vascular or surrounding structures. However, the cone beam CT angiography in the CT image acquisition still exist some issues which not be solved. Such as the image distortion at off-center in cone beam FOV, reduction of the image quality caused by x-ray scattering and the radiation dose from cone beam CT image acquisition. Our department (Chung-Shan Medical University Hospital) will purchase this type of cone beam CT angiography system in February 2007. We will deeply investigate the image quality and the radiation dosimetry in this imaging system. By the cooperation in the radiation division, it will be expected to achieve the following goals: (1) compare the imaging performance between the cone beam CT angiography and the conventional angiography; (2) develop an x-ray scattering control and reduction technique for cone beam CT; (3) employ an imaging simulation phantom to correct the image distortion and artifacts; and (4) validate the dose distribution measured by the TLDs and CT dose index during the con beam CT acquisition and establish an optimization protocol to reduce the unnecessary radiation dose. According to our knowledge, we would like to emphasize that this project would be the pioneer of its kind in Taiwan to explore the valuable main theme of evolutionary cone beam CT angiography. We strongly believe that the outcomes, if successfully being conducted through this study, will result in the start of a clinical study and definitely attract many attentions on the fields of angiography not only in Taiwan but also in an international level.儘管各式新穎的醫學影像診斷儀器不斷的在進步，如電腦斷層、磁振造影或超音波 等，但血管攝影(angiography)仍然是診斷血管疾病上的最佳利器。傳統的血管攝影儀是 利用影像增強管(image intensify tube)作為取像的接收器，近期由於平板式偵檢器(flat panel detector)的開發與錐形射束電腦斷層技術的成熟，今年廠商首次推出錐形射束電腦 斷層血管攝影儀(cone beam CT angiography system)，平板式偵檢器除了比傳統影像增強 管提供更高的空間解析度以及高信號雜訊比的優點外；配合錐形射束電腦斷層的技術， 也可提供三度空間的血管影像，另外還可同時應用在即時的三維解剖影像資訊的擷取， 若將二者的資訊整合，即能提供三度空間的血管影像與三維解剖影像整合為一體的資 訊，使得在診斷上能更清楚的瞭解血管交錯與周邊相關軟組織或器官的關係。 不過錐形射束電腦斷層血管攝影在三度空間CT 的取像上還有許多問題亟需解決， 特別是在錐形射束電腦斷層周圍影像的扭曲變形(image distortion)、錐形X 光射束散射 造成影像品質的降低以及三維解剖影像擷取的輻射劑量等議題。本校(中山醫學大學)附 設醫學中心將於96 年二月購置一部新型錐形射束電腦斷層血管攝影儀，因此，我們將 針對此技術作深入的影像品質分析及輻射劑量評估，藉由本院放射診斷部之研究團隊成 員的全力支持與配合下，本研究預期將能?成以下目標：(1)比較錐形電腦斷層血管攝影 與傳統血管攝影在造影技術及影像表現上的差異；(2)發展一套修正技術以解決因錐形射 束所產生之X 光散射問題；(3)利用影像模擬假體來評估並校正所產生之影像失真及假 影之問題；(4)利用熱發光劑量計與電腦斷層劑量指標評估錐形電腦斷層血管攝影於病人 所接受之輻射劑量，並找出最佳影像造影參數以減少病人接受不必要的輻射劑量。據我 們瞭解，在台灣，目前尚未有任何錐形電腦斷層血管攝影的相關研究，國際上，即使相 關文獻也甚為少數。吾人相信，此研究計畫的結果將必定會吸引血管攝影相關領域的重 視且提供作為未來臨床使用之參考。血管攝影錐形射束電腦斷層影像品質輻射劑量angiographycone beam CTimage qualityradiation doseProject