KANG-HSI WU2026-10-162026-10-162013-10-01Pure ID: 15339511Pure UUID: 94b5dce0-1fef-4c58-9376-1281f53cc5a910.1007/s11255-012-0178-0https://www.scopus.com/pages/publications/84887118531https://scholars.csmu.edu.tw/handle/123456789/32358The pathogenesis of renal involvement in Wiskott-Aldrich syndrome (WAS) is unclear and renal outcome is generally poor in such situations. Here we present the case of an 8-year-old boy with WAS who developed hematuria, proteinuria, and declining renal function that did not improve with the combined use of immunosuppressive agents and angiotensin-converting-enzyme inhibitor. Renal pathology revealed IgA nephropathy (IgAN). The patient underwent splenectomy for refractory thrombocytopenia. The proteinuria remitted and renal function improved after splenectomy, long-term antibiotic prophylaxis, and tapering of immunosuppressive agents.6enjournal article