2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38834Evaluate the Immune function of local Taiwan pine extraction and encourage its merchandise industrialization People have all along been seeking to prolong life. In the ancient China’s books, [Shen Nong Ben Cao Jing] and [Bencao Gangmu], mention that pines are the best drugs for lengthen human life and to be the health foods. Pinus morrisonicola Hayata is an original coniferous species in Taiwan. To investigatethe the bio-effects of Pinus morrisonicola Hayata, we will carry out the detailed analysis of the reactive components using HPLC, GC-MS, LC-MS, IR and NMR spectroscopy to isolate and analyze the intermediates and major or minor compounds that could reveal the true effects in the activity of immune function. The extracts of Pinus morrisonicola Hayata and the products from the companies will be evaluated the immune functions (immune cell proliferation, the expressions of cytokines and chemokines, the activation of NK cells, macrophage phagocytosis, the population of immune cells, B cell function, in vivo tests and human body tests) and toxicity studies (genotoxicity study, 28-day feeding toxicity study, 90-day feeding toxicity study, teratogenicity, carcinogenicity study and reproduction study). Besides, we will encourage the products of Pinus morrisonicola Hayata to be the merchandise industrialization.台灣本土五葉松萃取物免疫功能評估及促進其商品產業化 在古代中國的「神農本草經」描述能維持生命有助於長壽者則是「上 藥」，在「上藥」中，最先被提到的就是「松」，神農氏在幾千年前選 出了「長生十傑」，「松」既是『日、山、水、石、松、雲、木、草、 鶴、龜』這長生十傑之一。松葉、松毬果的藥效，自古以來就當成民間 藥及健康食品來使用，而且得到許多好的證明。宋朝時，「重修政和經 史證類備用本草」一書中，曾有如下之記載「松，可生毛髮、安內臟、 癒空腹，長生」。明朝李時珍著作，有漢方聖經之稱的「本草綱目」中 記載：「能夠治療腫疱、促進毛髮的再生、強健內臟（肝、腎、脾、心、 肺五臟）、能夠充飢、延年益壽。」述說松葉的藥效；亦曾記載松的藥 效「松葉名松毛。苦、溫、無毒。能生髮、安五臟、解飢、延天年」。 因此為推廣松的生物保健功能，同時又以台灣現有之本土保健物種五葉 松為主，採集本土北（五寮尖、石碇筆架山、皇帝殿）、中（秀巒、谷 關、惠蓀林場、大坑頭嵙山）、南（多納林道、鳳崗、扇平、南橫向陽 -利稻）區野生種及人工培育種之台灣五葉松樣本（針葉、幼莖、毬果）， 以進行五葉松萃取物製備及化學結構和成份分析、五葉松萃取物生物免 疫功能評估、五葉松萃取物生物安全性評估、台灣本土五葉松萃取物商 品化（雛形產品測試開發）及台灣本土五葉松產業化（試量產技術開發） 之研究。Project