PEI-CHENG LINHAN-HSIN CHANG2026-10-162026-10-162019-01-01Pure ID: 14947532Pure UUID: 7c0ddd9b-f8c0-47b6-9be7-59cd02ac7b2d10.37290/ctnr2641-452x.17:401-405https://www.scopus.com/pages/publications/85126688458https://scholars.csmu.edu.tw/handle/123456789/24693Oxygen supply is crucial to the health of avascular human cornea where low-oxygen-transmissible soft contact lenses often cause keratitis upon excessive wear time. Caffeic acid phenethyl ester, an active component of propolis, has anti-oxidative and anti-inflammatory properties. This study investigated the in vitro effects of caffeic acid phenethyl ester on corneal inflammation and its underlying action. We measured NF-κB activity and Dichloro-dihydro-fluorescein diacetate staining to demonstrate that caffeic acid phenethyl ester ameliorates hypoxia-induced inflammation of corneal endothelial cells and reactive oxygen species formation. The results may provide a new strategy to mitigate keratitis by caffeic acid phenethyl ester treatment.1enjournal article